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Updated: May 12, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
Published on: January 16, 2019
Complex inheritance for susceptibility to sudden cardiac death
Raha Pazoki1, Michael W T Tanck, Arthur A M Wilde
1Department of Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center Amsterdam (AMC), PO Box 22660, 1100 DD Amsterdam, The Netherlands. r.pazoki@amc.uva.nl.
Abstract:
Sudden cardiac death (SCD) from ventricular fibrillation during myocardial infarction is a leading cause of total and cardiovascular mortality. It has a multifactorial, complex nature and aggregates in families, implicating the involvement of heritable factors in the determination of risk. During the last few years, genome-wide association studies have uncovered common genetic variants modulating risk of SCD. We here review the current insight on genetic determinants of SCD in the community and describe the genome-wide association approaches undertaken thus far in uncovering genetic determinants of SCD risk.
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