Lymphomatoid granulomatosis of the skin. A new clinocopathologic entity

Lymphomatoid granulomatosis is a necrotizing arteritis primarily affecting the lungs but also found in the skin, kidneys, central nervous system, and other extra-pulmonary sites. Cutaneous involvement occurred in 45% of the cases described by Liebow in his original series. Light microscopy studies were performed. The IgA and IgG levels were slightly decreased and the IgE level was elevated. Cell-mediated immunity was impaired. No viruses were isolated or identified by immunofluorescence. A man had cutaneous lesions as the first sign of lymphomatoid granulomatosis.