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Updated: May 12, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
The chiasm: transfusion practice versus patient blood management
Donat R Spahn1, Aryeh Shander, Axel Hofmann
1Institute of Anesthesiology, Section Head Medical, Anesthesiology - Intensive Care Medicine - OR-Management, University and University Hospital Zurich, CH-8091 Zurich, Switzerland. donat.spahn@usz.ch
Allogeneic red blood cell (RBC) transfusions increase mortality and adverse outcomes. Patient blood management (PBM) minimizes RBC transfusions by treating anemia and reducing blood loss, improving patient outcomes.
Area of Science:
- Transfusion Medicine
- Patient Blood Management
- Anesthesiology
Background:
- Allogeneic red blood cell (RBC) transfusions are linked to increased mortality and adverse clinical outcomes.
- Key risk factors include preoperative anemia, significant perioperative blood loss, and liberal transfusion triggers.
Purpose of the Study:
- To highlight the importance of Patient Blood Management (PBM) as a strategy to mitigate risks associated with RBC transfusions.
- To emphasize the adoption of PBM as a global standard of care.
Main Methods:
- Patient Blood Management (PBM) integrates preoperative anemia treatment.
- PBM includes strategies to minimize perioperative blood loss.
- PBM focuses on optimizing patient tolerance to anemia.
Main Results:
- PBM aims to reduce the need for RBC transfusions.
- Improved clinical outcomes are a primary goal of PBM implementation.
- Australia is noted as a global leader in PBM implementation.
Conclusions:
- Patient Blood Management (PBM) is crucial for improving patient safety and outcomes.
- The World Health Organization endorses PBM as the standard of care.
- Widespread implementation of PBM is encouraged globally.
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