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Related Concept Videos

Complement System01:27

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a membrane...
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Glomerular Filtration Rate and its Regulation01:28

Glomerular Filtration Rate and its Regulation

The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...

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Updated: May 12, 2026

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
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High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

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[Complement system regulation and C3 glomerulopathy].

Hui-jie Xiao1, Rui-juan He

  • 1Department of Pediatrics, Peking University First Hospital, Beijing 100034, China. huijiexiao2@hotmail.com

Beijing Da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences
|April 18, 2013
PubMed
Summary
This summary is machine-generated.

Excessive complement system activation, particularly the alternative pathway, is implicated in glomerulonephritis. C3 glomerulopathy, marked by C3 deposition, may be treated by inhibiting this overactive complement pathway.

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High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
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Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
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Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

Area of Science:

  • Immunology
  • Nephrology

Context:

  • The complement system is crucial for immune surveillance and maintaining bodily balance.
  • Dysregulation of the complement system, especially the alternative pathway, is increasingly linked to glomerulonephritis pathogenesis.
  • C3 glomerulopathy is a distinct kidney disease defined by substantial C3 deposition in glomeruli without significant immunoglobulin presence.

Purpose:

  • To explore the role of complement system dysregulation in C3 glomerulopathy.
  • To highlight the diagnostic features and variable clinical spectrum of C3 glomerulopathy.
  • To identify potential therapeutic targets for C3 glomerulopathy.

Summary:

  • C3 glomerulopathy is characterized by significant C3 deposition in the glomeruli, often with reduced plasma C3 and Factor H levels.
  • This condition indicates a failure in the normal regulation of the complement system's alternative pathway.
  • Clinical presentations, treatment responses, and prognoses for C3 glomerulopathy are highly variable.

Impact:

  • Understanding the role of complement activation is key to diagnosing and managing C3 glomerulopathy.
  • Targeting excessive complement activation presents a promising therapeutic strategy for C3 glomerulopathy.
  • This research contributes to the evolving understanding of complement-mediated kidney diseases.