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Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model
Published on: September 8, 2023
Mandibular trabecular bone structure in adults with Crohn's disease
Grethe Jonasson1, Fredrik Lindberg, Alberto Jorge
1Research and Development Center, Sven Eriksonplatsen 4, Southern Älvsborg County, 503 38, Borås, Sweden, grethe.jonasson@vgregion.se.
Clinical Oral Investigations
|April 18, 2013
Summary
Individuals with Crohn's disease (CD) exhibit significantly sparser mandibular trabecular bone compared to healthy controls. Early identification of bone changes in CD patients may help prevent future fractures.
Area of Science:
- Oral radiology
- Bone metabolism
- Gastroenterology
Background:
- Crohn's disease (CD) is linked to decreased bone mineral density.
- Assessing mandibular trabecular bone quality is crucial for understanding systemic bone health in CD patients.
Purpose of the Study:
- To evaluate mandibular trabecular bone quality in Crohn's disease patients.
- To compare bone quality with age- and sex-matched controls.
- To identify background variables influencing bone density.
Main Methods:
- Intraoral radiographs of 49 CD patients and 49 controls were analyzed.
- Mandibular trabecular pattern was classified (sparse, mixed, dense).
- Computer-based methods assessed trabecular and intertrabecular spaces.
Main Results:
- CD patients demonstrated significantly sparser trabeculation on dental radiographs.
- CD patients had higher rates of smoking and maternal fragility fractures.
- A higher fracture rate was observed in CD patients, particularly smokers.
Conclusions:
- Trabecular bone is significantly sparser in individuals with Crohn's disease.
- Early identification of sparse trabeculation in CD patients can guide interventions to reduce fracture risk.
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