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Updated: May 12, 2026
DiI-Labeling of DRG Neurons to Study Axonal Branching in a Whole Mount Preparation of Mouse Embryonic Spinal Cord
Published on: December 13, 2011
Expression pattern of Nogo-A, MAG, and NgR in regenerating urodele spinal cord
Subhra Prakash Hui1, James R Monaghan, S Randal Voss
1Department of Biophysics, Molecular Biology and Bioinformatics, University of Calcutta, Kolkata, India.
Background:
The mammalian central nervous system is incapable of substantial axon regeneration after injury partially due to the presence of myelin-associated inhibitory molecules including Nogo-A and myelin associated glycoprotein (MAG). In contrast, axolotl salamanders are capable of considerable axon regrowth during spinal cord regeneration.
Results:
Here, we show that Nogo-A and MAG, and their receptor, Nogo receptor (NgR), are present in the axolotl genome and are broadly expressed in the central nervous system (CNS) during development, adulthood, and importantly, during regeneration. Furthermore, we show that Nogo-A and NgR are co-expressed in Sox2 positive neural progenitor cells.
Conclusions:
These expression patterns suggest myelin-associated proteins are permissive for neural development and regeneration in axolotls.
