Determination of absolute configuration of secondary alcohols using thin-layer chromatography
Alexander J Wagner1, Scott D Rychnovsky
1Department of Chemistry, 1102 Natural Sciences II, University of California-Irvine, Irvine, California 92627, United States.
Abstract:
A new implementation of the competing enantioselective conversion (CEC) method was developed to qualitatively determine the absolute configuration of enantioenriched secondary alcohols using thin-layer chromatography. The entire process for the method requires approximately 60 min and utilizes micromole quantities of the secondary alcohol being tested. A number of synthetically relevant secondary alcohols are presented. Additionally, (1)H NMR spectroscopy was conducted on all samples to provide evidence of reaction conversion that supports the qualitative method presented herein.
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