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[Validity of the use of penbutolol in essential arterial hypertension]
S Pepe1, G Scalici, A D'Angelo
1Cattedra di Fisiopatologia Medica, Università degli Studi di Palermo.
Insights
Penbutolol effectively lowers blood pressure in patients with mild to moderate hypertension. This beta-blocker showed no adverse effects on heart rate, kidney function, or lipid metabolism.
Area of Science:
- Cardiology
- Pharmacology
Context:
- Essential arterial hypertension (WHO I-II class) affects a significant patient population.
- Management of hypertension requires effective and safe therapeutic options.
Purpose:
- To evaluate the antihypertensive effectiveness of Penbutolol.
- To assess the impact of Penbutolol on heart frequency, lipid metabolism, and kidney function.
Summary:
- Thirty patients with mild-moderate essential hypertension received daily Penbutolol.
- Penbutolol significantly reduced systolic and diastolic arterial pressure values.
- No adverse effects were observed on lipid metabolism, kidney function, or heart frequency.
Impact:
- Penbutolol is a safe and effective treatment for mild-moderate essential hypertension.
- Daily administration of Penbutolol demonstrates a favorable safety profile.
- Findings support Penbutolol as a viable therapeutic option in hypertension management.
Abstract:
Thirty patients suffering from WHO I-II class slight-moderate essential arterial hypertension were treated with a beta-blocker (Penbutolol) alone and once a day to assess its antihypertensive effectiveness and its affect on heart frequency, lipid metabolism and kidney function. The drug proved highly effective in reducing P.A.S. and P.A.D. values and no negative influence was documented on lipid metabolism, kidney function or heart frequency.