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Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery
Published on: August 22, 2016
A simple new competition assay for heparin binding in serum applied to multivalent PAMAM dendrimers
Stephen M Bromfield1, Paola Posocco, Maurizio Fermeglia
1Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.
Chemical Communications (Cambridge, England)
|April 19, 2013
Abstract:
We report a competition assay using our recently reported dye Mallard Blue, which allows us to identify synthetic heparin binders in competitive media, including human serum - using this we gain insight into the ability of PAMAM dendrimers to bind heparin, with the interesting result that low-generation G2-PAMAM is the preferred heparin binder.
