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Optimization of brain targeted chitosan nanoparticles of Rivastigmine for improved efficacy and safety
Kalpana Nagpal1, S K Singh, D N Mishra
1Department of Pharmaceutical Sciences, Guru Jambeshwar University of Science & Technology, Hisar, Haryana 125001, India. kalpananagpal@gmail.com
Abstract:
The study aims at formulation and optimization brain targeted nanoparticles (NP) of Rivastigmine (RT) to improve its therapeutic potential and to verify its safety profile. The NP were optimized using a two factor three level (3(2)) central composite design aiming to minimize particle size; maximize zeta potential and drug entrapment efficiency of NP. The optimized formulation (cRTNP) was evaluated using in vitro drug release study; in vivo behavioral, and biochemical and maximum tolerated dose (MTD) study. The optimized formulation evidenced a significant reversal of scopolamine-induced amnesia by Tween 80(®) coated nanoparticles as compared to both pure RT as well as uncoated nanoparticles. The MTD of RT was increased by 10% by formulating them as cRTNP. Thus, formulation of RT as cRTNP improved the therapeutic and safety profile of RT.
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