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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Introduction to Fibroblasts01:09

Introduction to Fibroblasts

Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
Fibril-associated Collagen01:11

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

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Related Experiment Video

Updated: May 12, 2026

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus
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Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

Localized cutaneous fibrosing disorders.

Aaliya Yaqub1, Lorinda Chung, Kerri E Rieger

  • 1Division of Immunology and Rheumatology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.

Rheumatic Diseases Clinics of North America
|April 20, 2013
PubMed
Summary

This article differentiates skin disorders mimicking systemic sclerosis, focusing on localized conditions like morphea and eosinophilic fasciitis. It highlights key clinical and histopathologic features for accurate diagnosis and treatment of these sclerotic skin diseases.

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Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

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Published on: October 14, 2021

Area of Science:

  • Dermatology
  • Rheumatology
  • Pathology

Background:

  • Systemic sclerosis is a complex autoimmune disease.
  • Several skin disorders can clinically resemble systemic sclerosis.
  • Accurate differentiation is crucial for appropriate patient management.

Purpose of the Study:

  • To review skin disorders that mimic systemic sclerosis.
  • To emphasize distinguishing features for diagnosis.
  • To briefly discuss treatment options.

Main Methods:

  • Review of clinical and histopathologic findings.
  • Comparison of localized sclerotic disorders with systemic sclerosis.
  • Literature synthesis on differential diagnosis.

Main Results:

  • Identified localized scleroderma (morphea), eosinophilic fasciitis, scleredema, scleromyxedema, nephrogenic systemic fibrosis, and chronic graft-versus-host disease as mimics.
  • Detailed key clinical and histopathologic features for differentiation.
  • Provided a basis for distinguishing these from systemic sclerosis.

Conclusions:

  • Accurate differentiation of these disorders from systemic sclerosis is achievable through careful evaluation of clinical and histopathologic data.
  • Understanding these distinctions guides appropriate therapeutic strategies.
  • This review aids clinicians in managing patients with sclerotic skin conditions.