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Preparation of Mechanically Stable Self-Assembled Peptides Hydrogels
Published on: September 6, 2024
Enzyme-triggered hydrogelation via self-assembly of alternating peptides
Xu Qin1, Wenchun Xie, Sai Tian
1Center for Biocatalysis and Bioprocessing of Macromolecules, The Polytechnic Institute of New York University, Six Metrotech Center, Brooklyn, New York 11201, USA.
Chemical Communications (Cambridge, England)
|April 20, 2013
Abstract:
α-Chymotrypsin catalyzed oligomerization of the "dipeptide lego" KL-ethyl ester (OEt) in aqueous media triggers a rapid sol-gel transition due to formation of alternating (KL)x. Resulting mixed chain oligomers, at alkaline pH, self-assemble into β-sheets. Thereafter, intermolecular backbone hydrogen bonding between peptides causes formation of physically entangled nanofibrillar networks.
