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Updated: May 12, 2026

Localized RNAi and Ectopic Gene Expression in the Medicinal Leech
Published on: April 17, 2008
Flap infection associated with medicinal leeches in reconstructive surgery: two new drug-resistant organisms
Christopher Bibbo1, Thomas Fritsche, Mary Stemper
1Department of Orthopaedics, Marshfield Clinic, Marshfield, Wisconsin 54449, USA. cbibbo@charter.net
Abstract:
The use of medicinal leeches in reconstructive surgery has proven value for the salvage of flaps with venous congestion but is associated with a risk of leech-acquired infection. The most common leech-associated organism is Aeromonas hydrophila, which antibiotic prophylaxis is typically directed against. The authors describe two new multidrug-resistant organisms acquired from medicinal leech therapy that resulted in flap infection. The evaluation of suspected leech-borne infection and management protocol for this leech-acquired resistant multi-organism infection is presented.