Gingival crevicular fluid as a periodontal diagnostic indicator- II: Inflammatory mediators, host-response modifiers...

There has been a steady growing trend during the last few decades to develop tools to monitor periodontitis, in the field of oral disease diagnosis. Since GCF has the chance of being closely approximated to the periodontal tissues where periodontal disease begins, it seems to provide more information than markers in saliva. In response to bacterial infection, host production of inflammatory mediators, may be the trigger for periodontal disease progression. Existing paradigms in the biology of periodontitis have supported the detection of elevated levels of these mediators in GCF. This article is the Part II of the review that deals with inflammatory mediators and host-response modifiers as the potential biomarkers present in gingival crevicular fluid (GCF) and the chair side point-of-care diagnostic aids applicable to monitor periodontal inflammation.