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Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
Published on: August 12, 2019
Fast presurgical functional mapping using task-related intracranial high gamma activity.
Tianyi Qian1, Wenjing Zhou, Zhipei Ling
1Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China.
Journal of Neurosurgery
|April 23, 2013
Summary
High gamma activity detected via electrocorticography (ECoG) reliably maps motor functions. This ECoG mapping method proved more efficient and accurate than direct electrical cortical stimulation (ECS) and fMRI for presurgical planning.
Area of Science:
- Neuroscience
- Neurosurgery
- Medical Imaging
Background:
- Electrocorticography (ECoG) records brain activity.
- High gamma band power increases during motor tasks.
- ECoG is used for presurgical functional mapping.
Purpose of the Study:
- Validate clinical use of high gamma ECoG for motor mapping.
- Compare ECoG mapping with direct electrical cortical stimulation (ECS) and fMRI.
- Assess accuracy and efficiency of ECoG mapping.
Main Methods:
- Seventeen epilepsy patients underwent ECoG recording during hand/tongue movements.
- ECS mapping was performed on all patients.
- fMRI was used in eight patients.
- General Linear Model (GLM) analyzed high gamma activity for mapping.
Main Results:
- GLM-based ECoG mapping localized motor regions consistent with ECS.
- ECoG mapping showed higher sensitivity than fMRI (66.7% vs 52.6%).
- Both ECoG and fMRI had high specificity (>97%).
- ECoG mapping achieved near-perfect accuracy when accounting for ECS current spread.
Conclusions:
- GLM-based ECoG mapping is efficient and accurate for presurgical motor function localization.
- Motor functions can be reliably mapped in under 5 minutes using this ECoG technique.
- ECoG offers superior performance compared to ECS and fMRI.
