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Risk stratification in medullary thyroid cancer: moving beyond static anatomic staging
1Endocrinology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. tuttlem@mskcc.org
Oral Oncology
|April 23, 2013
Summary
Risk stratification for medullary thyroid cancer evolves over time. Dynamic re-evaluation of risk factors and response to therapy improves patient management and outcomes.
Area of Science:
- Endocrinology
- Oncology
- Thyroid Cancer Research
Background:
- Risk stratification in differentiated thyroid cancer has advanced with dynamic re-evaluation approaches.
- Clinico-pathologic factors correlate with outcomes in medullary thyroid cancer, similar to differentiated types.
Purpose of the Study:
- To re-examine initial risk factors in medullary thyroid cancer.
- To re-evaluate how risk factors change over time reflecting response to therapy and disease course.
Main Methods:
- Review of existing literature on medullary thyroid cancer risk factors.
- Application of response-to-therapy nomenclature from differentiated thyroid cancer.
Main Results:
- Initial risk factors in medullary thyroid cancer are clinically important.
- Risk estimates can be altered over time based on clinical course and therapeutic response.
Conclusions:
- A validated response-to-therapy nomenclature for differentiated thyroid cancer can be applied to medullary thyroid cancer.
- This nomenclature aids in guiding ongoing clinical management for medullary thyroid cancer patients.
