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Single centre experience: long term outcomes in spina bifida patients
Georgina Malakounides1, Frank Lee, Feilim Murphy
1Department of Paediatric Urology, St George's Hospital, Blackshaw Road, Tooting, London SW17 0QT, UK. georgina@doctors.org.uk
Journal of Pediatric Urology
|April 23, 2013
Summary
Long-term renal function in spina bifida patients is generally good, with low rates of severe impairment. This study suggests improved survival and reduced renal complications, offering a more optimistic outlook for families.
Area of Science:
- Urology
- Pediatric Nephrology
- Spina Bifida Research
Background:
- Spina bifida is associated with significant renal morbidity and mortality.
- Historical data indicates a high risk of kidney complications in affected individuals.
Purpose of the Study:
- To evaluate long-term renal function in spina bifida patients.
- To assess mortality rates within a spina bifida cohort.
- To update prognostic information for families.
Main Methods:
- Prospective data collection from 1970-2011.
- Inclusion of spina bifida patients managed at a single center.
- Analysis of glomerular filtration rates, renal imaging, management, and mortality.
Main Results:
- 120 patients analyzed (mean age 20 years).
- 48% demonstrated normal renal function.
- Only 1.6% had severe renal impairment or end-stage renal failure.
- Overall mortality rate was 4.4%, with no deaths attributed to renal failure.
Conclusions:
- Current spina bifida patient outcomes show better renal function and survival than historical data suggests.
- Advancements in care have likely reduced renal morbidity and mortality.
- Counseling for families can be more optimistic regarding long-term survival.
