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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Triazolothiadiazoles and triazolothiadiazines--biologically attractive scaffolds
Imtiaz Khan1, Aliya Ibrar, Naeem Abbas
1Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan. ikhanqau@gmail.com
Abstract:
Contemporary medicinal chemistry faces diverse challenges from several directions, including the need for both potency and specificity of any therapeutic agent. Therefore, in the present perspective, the triazolothiadiazoles and triazolothiadiazines with broad spectrum biological profile have matured into indispensable heterocyclic scaffolds. This review article is an effort to summarize medicinal chemistry investigations over the last decade, in search for new N-bridged heterocycles which can be a rich source of promising biological activities.
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Separation of the aromatic...
