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Updated: May 12, 2026

Imaging Denatured Collagen Strands In vivo and Ex vivo via Photo-triggered Hybridization of Caged Collagen Mimetic Peptides
Published on: January 31, 2014
Design of net-charged abc-type collagen heterotrimers
Avanish S Parmar1, Sohail Zahid1, Sandeep V Belure1
1Department of Biochemistry and Molecular Biology, Robert Wood Johnson Medical School, UMDNJ and Center for Advanced Biotechnology and Medicine, Piscataway, NJ 08854, United States.
Abstract:
Net-negatively-charged heterospecific A:B:C collagen peptide heterotrimers were designed using an automated computational approach. The design algorithm considers both target stability and the energy gap between the target states and misfolded competing states. Structural characterization indicates the net-negative charge balance on the new designs enhances the specificity of the target state at the expense of its stability.
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