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Updated: May 12, 2026

18F-Labeling of Radiotracers Functionalized with a Silicon Fluoride Acceptor (SiFA) for Positron Emission Tomography
Published on: January 11, 2020
(18)F-FDG PET/CT imaging of metastatic atypical fibroxanthoma
Sindu Sheth1, Andrew Kim, William D Bishop
1LAC+USC Medical Center Division of Nuclear Medicine, Department of Radiology, Keck School of Medicine at University of Southern California, Los Angeles, CA 90033, USA. sindusheth@yahoo.com
Abstract:
We report the F-FDG PET/CT appearance of a metastatic biopsy-proven malignant fibroxanthoma of the ankle. A 41-year-old female patient with a history of scleroderma presented with a fungating mass in the left ankle. Shave biopsy of the overlying skin showed atypical fibroxanthoma (AFX). Staging FDG PET/CT demonstrated a hypermetabolic exophytic soft tissue mass in the left ankle with local extension to bone and widespread metastatic disease including pulmonary parenchyma, nodes, bone marrow, and skeletal muscle. While rare, knowledge of the potential aggressive nature of AFX is important for accurate diagnosis.
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