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Updated: May 12, 2026

An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
Non-peptidyl insulin mimetics as a potential antidiabetic agent
Rakesh P Nankar1, Mukesh Doble
1Bioengineering and Drug Design Lab, Department of Biotechnology, Indian Institute of Technology Madras, Chennai 600036, India.
Abstract:
Insulin has an important role in the maintenance of blood sugar. It is the only available therapeutic agent for the treatment of type 1 diabetes mellitus and there is a dire need for an oral substitute. Different categories of compounds including mono and di substituted benzoquinones, vanadium based compounds and natural products have been reported to cause insulin-like effects either by increasing phosphorylation of insulin receptor (IR) or inhibiting the protein tyrosine phosphatases. This review summarizes the development of various insulin mimetics with special emphasis on their structure-activity relationships and various biological actions they produce.
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