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Related Concept Videos

Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.

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Related Experiment Video

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In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

PhenoMiner: quantitative phenotype curation at the rat genome database.

Stanley J F Laulederkind1, Weisong Liu, Jennifer R Smith

  • 1Human and Molecular Genetics Center, Medical College of Wisconsin, Human and Molecular Genetics Center, 8701 Watertown Plank Rd, Milwaukee, WI 53226-3548, USA. slaulederkind@mcw.edu

Database : the Journal of Biological Databases and Curation
|April 23, 2013
PubMed
Summary
This summary is machine-generated.

The Rat Genome Database (RGD) now integrates quantitative phenotype data for rat strains, enhancing its comprehensive collection of genomic and genetic information. This expansion supports deeper biological insights and research into complex traits and diseases.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Phenomics

Background:

  • The Rat Genome Database (RGD) is a primary resource for rat genomic, genetic, and phenotypic data.
  • Existing RGD data includes genes, quantitative trait loci (QTLs), strains, and associated biological information.
  • Current curation primarily focuses on qualitative phenotype data.

Purpose of the Study:

  • To expand the RGD by incorporating quantitative phenotype data for rat strains.
  • To develop a specialized curation tool for manual annotation of quantitative trait data.
  • To enhance the RGD's capacity for detailed biological and disease association studies.

Main Methods:

  • Development of a specialized curation tool capable of using up to six ontologies simultaneously.
  • Manual annotation of experimental values from literature into the RGD.
  • Expansion of three key ontologies to support new quantitative phenotype data curation.

Main Results:

  • Successful initiation of the PhenoMiner curation project at RGD.
  • Development of a sophisticated curation interface and ongoing ontology development.
  • Establishment of a framework for integrating quantitative phenotype data alongside existing qualitative data.

Conclusions:

  • The RGD's capacity to store and present quantitative phenotype data has been significantly enhanced.
  • The new curation tools and ontologies facilitate more comprehensive data integration and analysis.
  • This advancement supports more in-depth research into rat genetics, phenotypes, and disease models.