Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preclinical Pharmacology Characterization of Sovleplenib (HMPL-523), an Orally Available Syk Inhibitor.

The Journal of pharmacology and experimental therapeutics·2023
Same author

Comparative Genomic Analysis and Metabolic Potential Profiling of a Novel Culinary-Medicinal Mushroom, <i>Hericium rajendrae</i> (Basidiomycota).

Journal of fungi (Basel, Switzerland)·2023
Same author

Can neoadjuvant chemoradiotherapy combined with immunotherapy benefit patients with microsatellite stable locally advanced rectal cancer? a pooled and integration analysis.

Frontiers in oncology·2023
Same author

Headache attributed to giant cell arteritis complicated with rheumatic polymyalgia diagnosed with F18-fluorodeoxyglucose positron emission tomography and computed tomography: a case report.

Frontiers in neurology·2023
Same author

Effect of the inoculation of Phanerochaete chrysosporium on nitrogen migration and organic matter conversion during electrolytic manganese residue composting.

Bioresource technology·2023
Same author

Latency-associated peptide (LAP)<sup>+</sup>CD4<sup>+</sup> regulatory T cells prevent atherosclerosis by modulating macrophage polarization.

Clinical immunology (Orlando, Fla.)·2023
Same journal

FAM234A acts as a switch between Th17 and Treg cell fate decisions that control inflammatory bowel disease.

Cellular & molecular immunology·2026
Same journal

Targeting SPP1 requires moving beyond ligand blockade.

Cellular & molecular immunology·2026
Same journal

USP9X trims STAT1 to curb oncostatin M activity and intestinal inflammation.

Cellular & molecular immunology·2026
Same journal

Itaconate induces noncanonical AIM2-dependent PANoptosis in sepsis.

Cellular & molecular immunology·2026
Same journal

EZH2: an epigenetic governor of T-cell Ca<sup>2+</sup> homeostasis.

Cellular & molecular immunology·2026
Same journal

Vimentin trogocytosis as a novel mechanism of NK cell exhaustion by circulating tumor cells.

Cellular & molecular immunology·2026
See all related articles

Related Experiment Video

Updated: May 12, 2026

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
11:08

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Published on: February 14, 2025

NK cell-based immunotherapy for malignant diseases.

Min Cheng1, Yongyan Chen, Weihua Xiao

  • 1Institute of Immunology, University of Science and Technology of China, Hefei, China.

Cellular & Molecular Immunology
|April 23, 2013
PubMed
Summary
This summary is machine-generated.

Natural killer (NK) cells are crucial for fighting cancer, but tumors evade them. This review explores advanced NK cell immunotherapies and monitoring strategies to enhance cancer treatment efficacy.

More Related Videos

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions
08:17

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions

Published on: October 30, 2016

Isolation and Expansion of Cytotoxic Cytokine-induced Killer T Cells for Cancer Treatment
11:11

Isolation and Expansion of Cytotoxic Cytokine-induced Killer T Cells for Cancer Treatment

Published on: January 24, 2020

Related Experiment Videos

Last Updated: May 12, 2026

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells
11:08

Advances in Human Induced Pluripotent Stem Cell-Derived Chimeric Antigen Receptor-Expressing Natural Killer Cells

Published on: February 14, 2025

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions
08:17

Flow Cytometry-based Assay for the Monitoring of NK Cell Functions

Published on: October 30, 2016

Isolation and Expansion of Cytotoxic Cytokine-induced Killer T Cells for Cancer Treatment
11:11

Isolation and Expansion of Cytotoxic Cytokine-induced Killer T Cells for Cancer Treatment

Published on: January 24, 2020

Area of Science:

  • Immunology
  • Oncology
  • Cell Therapy

Background:

  • Natural killer (NK) cells are vital for anti-cancer immunity.
  • Cancers develop resistance mechanisms against NK cell surveillance.
  • Current NK cell immunotherapies aim to restore or enhance NK cell anti-tumor activity.

Purpose of the Study:

  • To review current NK cell-based cancer immunotherapies.
  • To discuss novel strategies for NK cell therapy development and application.
  • To introduce methods for monitoring and evaluating NK cell therapy efficacy.

Main Methods:

  • Review of clinical trials involving NK cell therapies.
  • Discussion of various NK cell expansion and genetic modification techniques.
  • Exploration of different NK cell sources and production methods.
  • Introduction of novel monitoring and evaluation strategies for NK cell therapy.

Main Results:

  • Multiple NK cell-based immunotherapy approaches are in clinical trials.
  • Strategies include allogeneic NK cells, NK cell lines, and genetically modified NK cells.
  • Diverse sources and large-scale production methods are available for therapeutic NK cells.
  • New techniques for non-invasive monitoring and in vivo/clinical evaluation are emerging.

Conclusions:

  • NK cell immunotherapy holds significant promise for cancer treatment.
  • Advancements in cell manufacturing and genetic engineering are expanding therapeutic options.
  • Effective monitoring and evaluation are crucial for successful clinical translation of NK cell therapies.