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Microembossing: A Convenient Process for Fabricating Microchannels on Nanocellulose Paper-Based Microfluidics

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Sensing approaches on paper-based devices: a review.

Emilia W Nery¹, Lauro T Kubota

¹Universidade Estadual de Campinas Instituto de Químíca, Caixa Postal 6154, 13083-970, Campinas, SP, Brazil.

Analytical and Bioanalytical Chemistry

|April 23, 2013

Summary

Paper is a versatile substrate for developing affordable, disposable sensors. This review highlights recent advances in optical and electrochemical paper-based sensors, excluding simple lateral flow tests.

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Area of Science:

Analytical Chemistry
Materials Science
Sensor Technology

Background:

Paper, a cellulosic material, offers numerous advantages for sensor development, including mechanical strength, biocompatibility, and low cost.
Its unique fibrous structure and ease of modification make it ideal for disposable sensors and integrated platforms.
Paper has a long history in analytical chemistry, now experiencing a resurgence as a sensor substrate.

Purpose of the Study:

To review prominent examples of paper-based sensors, categorized by detection methods.
To examine recent advancements in paper-based immunoassays, excluding nitrocellulose lateral flow tests.
To summarize the pros and cons of using paper as a sensor substrate and its impact on sensor performance.

Main Methods:

Classification of paper-based sensors based on optical detection (colorimetric, fluorescence, SERS, transmittance).
Classification of paper-based sensors based on electrochemical detection (voltammetric, potentiometric, conductivity).
Review of fabrication methods, paper sources, and historical context of paper in analytical chemistry.

Main Results:

Numerous optical and electrochemical paper-based sensors have been developed, demonstrating diverse applications.
Recent progress includes sophisticated immunoassays fabricated on paper substrates.
Paper offers significant advantages for sensor performance and application, despite some limitations.

Conclusions:

Paper is a highly suitable and cost-effective substrate for advanced disposable sensors and integrated sensing platforms.
Continued research into paper-based sensors promises further innovation in analytical chemistry and diagnostics.
The versatility of paper ensures its ongoing importance in the field of sensor technology.