Related Experiment Video
Updated: May 12, 2026

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
Published on: February 7, 2018
Morphologic assessment of oxidative damage: A review
1Pathology and Laboratory Medicine Service, Veterans Administration Hospital, Madison, WI ; Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison, WI ; Room A-35, VA Hospital, 2500 Overlook Terrace, Madison, WI.
Abstract:
Biochemical studies have indicated changes in anti-oxidant enzyme activities and increased oxidative damage products in many disease states, particularly aging and diseases associated with aging, such as neurodegenerative diseases and cancer. To try to determine cellular and subcellular localization of oxidative damage, our laboratory has developed quantitative light and electron microscopy immunogold techniques using specific antibodies to oxidative damage products. Results from studies of different pathologic processes are presented, illustrating that both localization and quantitation of oxidative damage products is possible. These analyses give important insights into the nature of various pathologic processes.
Related Concept Videos
Cellular Injury I: Introduction
Radical Autoxidation
Bioactivation and Tissue Toxicity
Phase I Oxidative Reactions: Overview
Cellular Injury II: Classification
Necrosis
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...

