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Following an experiment feeding Deoxynivalenol to growing pigs histological studies have been carried out to evaluate tissue damaging effects of DON. Pigs were fed with naturally contaminated wheat containing 4000 and 6000 µg DON/kg feed. A number of two animals was chosen from control and high exposed group, respectively. Samples of the gastrointestinal tract, liver and kidney were examined. Although, clear effects in feed consumption and weight gain could be realized, only one animal from the high exposed group showed focal alterations in tissues of the gastrointestinal tract.