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09:51
Human Liver Spheroids from Peripheral Blood for Liver Disease Studies
Published on: January 27, 2023
Hepatic manifestations in hematological disorders.
Jun Murakami1, Yukihiro Shimizu
1The Third Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.
International Journal of Hepatology
|April 23, 2013
Summary
Hematological disorders frequently impact the liver, causing abnormal tests and symptoms. Conditions like hemolytic anemia and hematologic malignancies can lead to liver dysfunction and failure.
Area of Science:
- Hepatology
- Hematology
- Internal Medicine
Background:
- Liver involvement is a common complication in various hematological disorders.
- Manifestations range from abnormal liver function tests to overt hepatic symptoms.
Purpose of the Study:
- To summarize the spectrum of liver involvement in hematological disorders.
- To highlight the diagnostic challenges and potential severity of hepatic manifestations.
Main Methods:
- Review of clinical presentations and laboratory findings in patients with hematological disorders and liver involvement.
- Analysis of imaging studies and pathological findings.
Main Results:
- Hemolytic anemia can present with jaundice and hepatosplenomegaly, mimicking primary liver disease.
- Hematologic malignancies frequently infiltrate the liver, causing abnormal liver function tests, hepatosplenomegaly, and nodules.
- These hepatic complications can progress to fulminant hepatic failure.
Conclusions:
- Hematological disorders represent a significant cause of liver abnormalities.
- Early recognition and management of liver involvement are crucial to prevent severe outcomes like liver failure.
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