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Acute Transverse Myelitis Associated with Buserelin Use during IVF
Djavid I Alleemudder1, Khaled Sadek, Shaun Fountain
1Salisbury District Hospital, Salisbury SP2 8BJ, UK.
Case Reports in Obstetrics and Gynecology
|April 23, 2013
Summary
A woman developed acute transverse myelitis (ATM) after receiving Buserelin during in vitro fertilization (IVF). This case suggests gonadotropin-releasing hormone agonists may trigger immune responses, potentially leading to neurological conditions like ATM.
Area of Science:
- Neuroimmunology
- Reproductive Endocrinology
Background:
- Acute transverse myelitis (ATM) is a neurological disorder.
- In vitro fertilization (IVF) involves hormonal treatments.
- Buserelin is a gonadotropin-releasing hormone (GnRH) agonist.
Purpose of the Study:
- To report a case of ATM following Buserelin use in IVF.
- To explore the potential role of GnRH agonists in immune-mediated neurological events.
Main Methods:
- Case report of a healthy woman undergoing IVF.
- Review of literature on ATM etiology and GnRH agonist mechanisms.
Main Results:
- The patient developed ATM after Buserelin administration.
- Literature suggests immune activation by infectious agents or GnRH agonists can trigger neurological conditions.
Conclusions:
- GnRH agonists, like Buserelin, may potentially trigger immune responses.
- This immune activation could precipitate neurological conditions such as ATM in susceptible individuals.