Related Experiment Video
Updated: May 12, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Synthesis and biological evaluation of some novel tetrahydroquinolines as anticancer and antimicrobial agents
Hassan M Faidallah1, Alaa A Saqer, Khalid A Alamry
1Department of Chemistry, Faculty of Science, King Abdulaziz University , Jeddah , Saudi Arabia and.
Abstract:
This study reports the synthesis of a series of new 2-amino-3-cyano-8-methyl-4-substituted-5,6,7,8-tetrahydroquinolines along with some derived fused-ring systems. Ten compounds have shown remarkable cytotoxic activity against human colon carcinoma HT29, hepatocellular carcinoma HepG2 and Caucasian breast adenocarcinoma MCF7 cell lines. Six compounds showed considerable broad-spectrum cytotoxic activity among which two proved to be the most active derivatives. Likewise, seven compounds from the series were found to exhibit significant antimicrobial activity and three of them proved to be the most active candidates. Two alkylthio-pyrimido quinolines are suggested as possible antimicrobial and anticancer candidates in the present series.
Related Concept Videos
Inhibitors of Bacterial DNA Synthesis
Gene Regulation in Microbial Communities: Quorum Sensing
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Drugs that Destabilize Microtubules

