Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epigenetic de-repression of basal cell metaplasia in aging AT2 cells is a risk factor for idiopathic pulmonary fibrosis (IPF).

bioRxiv : the preprint server for biology·2026
Same author

Transcriptional landscape of pulmonary artery endothelium reveals subpopulation- and disease-specific remodeling signatures.

Communications biology·2026
Same author

Alveolar Type II Cell-derived MMP1 <sup>high</sup> basal cells promote destructive microcysts in idiopathic pulmonary fibrosis.

bioRxiv : the preprint server for biology·2026
Same author

Cerebrospinal fluid draining lymphatics in health and disease: advances and controversies.

Nature cardiovascular research·2025
Same author

Normal Treg homeostasis and suppressive function require both FOXP1 and FOXP4.

JCI insight·2025
Same author

Mechanical force-mediated cellular crosstalk maintains the integrity of the lung gas exchange niche.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: May 12, 2026

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease
09:45

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

Molecular determinants of lung development.

Edward E Morrisey1, Wellington V Cardoso, Robert H Lane

  • 1Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Annals of the American Thoracic Society
|April 24, 2013
PubMed
Summary

Understanding pulmonary system development is key for lung health and disease. Research highlights how developmental pathways impact lung formation, repair, and disease, guiding future research and therapies.

More Related Videos

Mouse Embryonic Lung Culture, A System to Evaluate the Molecular Mechanisms of Branching
07:32

Mouse Embryonic Lung Culture, A System to Evaluate the Molecular Mechanisms of Branching

Published on: June 30, 2010

Studying Wnt Signaling During Patterning of Conducting Airways
13:00

Studying Wnt Signaling During Patterning of Conducting Airways

Published on: October 16, 2016

Related Experiment Videos

Last Updated: May 12, 2026

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease
09:45

Generation of 3D Whole Lung Organoids from Induced Pluripotent Stem Cells for Modeling Lung Developmental Biology and Disease

Published on: April 12, 2021

Mouse Embryonic Lung Culture, A System to Evaluate the Molecular Mechanisms of Branching
07:32

Mouse Embryonic Lung Culture, A System to Evaluate the Molecular Mechanisms of Branching

Published on: June 30, 2010

Studying Wnt Signaling During Patterning of Conducting Airways
13:00

Studying Wnt Signaling During Patterning of Conducting Airways

Published on: October 16, 2016

Area of Science:

  • Pulmonary Medicine
  • Developmental Biology
  • Molecular Biology

Background:

  • Pulmonary system development is crucial for life on land.
  • Molecular pathways regulating lung formation are increasingly understood.
  • This knowledge is vital for congenital and acquired lung diseases.

Purpose of the Study:

  • To summarize a workshop on pulmonary system development.
  • To identify key developmental principles and knowledge gaps.
  • To provide recommendations for advancing lung developmental biology.

Main Methods:

  • Workshop convened by the National Heart, Lung, and Blood Institute.
  • Discussions focused on four key topics: cell fate, differentiation, tissue interactions, and environmental impact.
  • Synthesis of emerging evidence and critical discussion points.

Main Results:

  • Key developmental pathways regulate lung formation, repair, and disease pathogenesis.
  • Advances include generating lung epithelium from pluripotent stem cells.
  • Identified knowledge gaps in epigenetic regulation, mesenchymal lineages, and cardiovascular interactions.

Conclusions:

  • Understanding lung development is critical for treating lung diseases.
  • Further research is needed on epigenetic regulation and mesenchymal lineages.
  • Recommendations aim to address knowledge gaps in lung developmental biology.