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Updated: May 12, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
09:49

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

Circulating microparticles: square the circle.

Natasha S Barteneva1, Elizaveta Fasler-Kan, Michael Bernimoulin

  • 1Program in Cellular and Molecular Medicine, Boston Children's Hospital, D-249, 200 Longwood Avenue, Boston, MA 02115, USA. Natasha.Barteneva@childrens.harvard.edu

BMC Cell Biology
|April 24, 2013
PubMed
Summary

Microparticles (MPs), cell-derived vesicles, transfer molecules between cells and are implicated in various diseases. Further research is needed to overcome technological challenges for their use as diagnostic biomarkers.

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Area of Science:

  • Biomedical research
  • Cell biology
  • Molecular diagnostics

Background:

  • Microparticles (MPs) are cell-derived vesicles (50-1000 nm) involved in intercellular communication.
  • MPs transfer various biomolecules, including peptides, proteins, lipids, microRNA, mRNA, and DNA.
  • MPs play a role in the development and progression of cancer and other diseases.

Purpose of the Study:

  • To review current knowledge on circulating microparticles (MPs).
  • To provide a systematic overview of research on MPs over the past 20 years.
  • To highlight the clinical relevance and diagnostic potential of MPs.

Main Methods:

  • Systematic literature review of research on circulating microparticles.
  • Analysis of studies focusing on the clinical relevance of MPs.

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Last Updated: May 12, 2026

Routine Screening Method for Microparticles in Platelet Transfusions
09:49

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Published on: January 31, 2018

Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells
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Published on: October 13, 2023

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  • Evaluation of current technological limitations in MP purification and detection.

    • Main Results:

    • MPs are heterogeneous vesicles involved in intercellular molecular transfer.
    • Circulating MPs are implicated in cancer, autoimmune, inflammatory, infectious, and cardiovascular diseases.
    • MPs show promise as diagnostic biomarkers, but standardization is lacking.

    Conclusions:

    • Deciphering MP molecular signatures is crucial for diagnostics.
    • Understanding MPs can aid in evaluating treatment efficacy.
    • Improved MP analysis may lead to better disease outcome prediction.