Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unveiling how mitotic spindle orientation in 3D human colon organoids affects matrix displacements through a 4D study using DVC.

Scientific reports·2025
Same author

Wastewater Surveillance to Estimate and Characterize Hepatitis E Virus Circulation.

Food and environmental virology·2025
Same author

High SARS-CoV-2 IgG seroprevalence among pregnant Cameroun women 14 months after the beginning of the pandemic.

Public health·2022
Same author

[Genotypic recombination and hepatitis C virus].

Virologie (Montrouge, France)·2022
Same author

Fecal Microbiota Transplantation for Refractory Clostridioides Difficile Infection Is Effective and Well Tolerated Even in Very Old Subjects: A Real-Life Study.

The journal of nutrition, health & aging·2022
Same author

[Rhabdomyolysis with tetraparesis secondary to hepatitis E virus infection in a patient on statins].

La Revue de medecine interne·2022
Same journal

[Etiology and clinical expression of angina].

Medecine et maladies infectieuses·2024
Same journal

[Rational use of antibiotics treatment in acute bronchitis].

Medecine et maladies infectieuses·2024
Same journal

Medecine et maladies infectieuses·2024
Same journal

[Detection of human rotaviruses in faeces : comparison of five methods].

Medecine et maladies infectieuses·2024
Same journal

Medecine et maladies infectieuses·2024
Same journal

Medecine et maladies infectieuses·2024
See all related articles

Related Experiment Video

Updated: May 12, 2026

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

Hepatitis E virus.

F Abravanel1, S Lhomme, M Dubois

  • 1Inserm, U563, centre de physiopathologie de Toulouse Purpan, 31300 Toulouse, France. abravanel.f@chu-toulouse.fr

Medecine Et Maladies Infectieuses
|April 24, 2013
PubMed
Summary
This summary is machine-generated.

Hepatitis E virus (HEV) causes acute hepatitis outbreaks globally. In developed nations, zoonotic HEV infections primarily affect older men, with chronic risks for immunocompromised individuals.

Keywords:
Chronic infectionHepatitis E virusInfection chroniqueVirus de l’hépatite E

More Related Videos

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
04:11

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

Published on: December 15, 2023

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

Related Experiment Videos

Last Updated: May 12, 2026

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
10:28

A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks

Published on: June 26, 2020

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
04:11

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

Published on: December 15, 2023

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

Area of Science:

  • Hepatology
  • Virology
  • Infectious Diseases

Background:

  • Hepatitis E virus (HEV) is a significant cause of acute hepatitis, historically linked to waterborne outbreaks in developing nations.
  • Recent years have seen increased focus on HEV in developed countries due to rising autochthonous (locally acquired) infections.
  • Hepatitis E is recognized as a zoonotic disease, with a notable prevalence in men over 50 years of age.

Purpose of the Study:

  • To review the epidemiology and clinical significance of Hepatitis E virus infections.
  • To highlight the challenges in diagnosing HEV and its implications for public health.
  • To discuss current treatment and vaccine development for Hepatitis E.

Main Methods:

  • Literature review of HEV epidemiology, clinical presentation, diagnosis, and treatment.
  • Analysis of HEV's role in both developing and developed countries.
  • Examination of HEV in immunocompetent versus immunocompromised patient populations.

Main Results:

  • HEV infections present similarly to other viral hepatitis in immunocompetent individuals.
  • HEV poses a significant risk for chronic infection in immunocompromised patients.
  • Diagnosis relies on serological tests and viral RNA detection; Ribavirin is a key treatment for the immunocompromised.

Conclusions:

  • Hepatitis E is an emerging public health concern globally, with distinct transmission routes and patient demographics.
  • Effective diagnostic methods are available, and treatment options like Ribavirin are established for specific populations.
  • While promising vaccines exist, regulatory approval for widespread use in Europe is pending.