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Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...

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Related Experiment Video

Updated: May 12, 2026

Surgical Models of Gastroesophageal Reflux with Mice

Surgical Models of Gastroesophageal Reflux with Mice

Published on: August 25, 2015

[Megaesophagus in the dog and cat].

S Mace¹, G D Shelton, S Eddlestone

¹Veterinary Specialty Center of the Hudson Valley, NY, USA.

Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere

|April 24, 2013

Summary

Megaesophagus, a disorder causing esophageal dilation and reduced peristalsis, has congenital and acquired forms. Diagnosing the underlying cause is crucial for effective treatment and prognosis.

Area of Science:

Veterinary Medicine
Gastroenterology
Pathology

Context:

Megaesophagus involves esophageal dilation and impaired peristalsis.
It presents in congenital and acquired forms.
Acquired megaesophagus links to various systemic disorders.

Purpose:

To define megaesophagus and its classifications.
To outline associated conditions and clinical signs.
To emphasize diagnostic approaches and treatment variability.

Summary:

Megaesophagus is characterized by esophageal dilation and decreased peristalsis, with congenital and acquired origins.
Acquired forms are linked to gastrointestinal, endocrine, immune, neuromuscular, paraneoplastic, and toxic conditions.
Clinical signs include regurgitation, weight loss, coughing, and halitosis, with diagnosis often requiring radiography and further investigation.

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Impact:

Highlights the importance of identifying underlying causes for tailored management.
Informs veterinary professionals on diagnostic pathways for megaesophagus.
Stresses the variable prognosis dependent on the etiology of megaesophagus.