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Updated: May 12, 2026

Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
Transcription factor STAT1 gene polymorphism is associated with the development of severe forms of periodontal
Adriana Machado Saraiva1, Jeane de Fátima Correia Silva, Micena Roberta Miranda Alves e Silva
1Laboratório de Biologia das Interações Celulares, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Pampulha, Belo Horizonte, MG CEP 31270-901, Brazil.
Introduction:
Periodontal disease (PD) is one of the most common inflammatory diseases, affecting about 10 % of the world population. The establishment of PD is influenced by polymorphisms in genes involved with the inflammatory response. Signal Transducer and Activator of Transcription (STAT)-1 is a transcription factor that plays a key role in the intracellular signaling triggered by cytokines and, thus, its activation is critical in inflammatory diseases.
Aim And Methods:
We aim to evaluate the occurrence of association between STAT-1 (rs3771300) polymorphism and distinct clinical forms and severity of PD; we genotyped 180 subjects using realtime PCR.
Results And Conclusion:
We observed that the presence of the G allele for STAT-1 was associated with twice as high of a chance to develop aggressive periodontitis, and the most severe form of the disease.
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