Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement activation before, during and after cardiopulmonary bypass.

R S Bonser1, J R Dave, L John

  • 1Department of Surgery, Brompton Hospital, London, UK.

European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-Thoracic Surgery
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world management of juvenile autoimmune liver disease.

United European gastroenterology journal·2018
Same author

Interferon-free therapy in hepatitis C virus mixed cryoglobulinaemia: a prospective, controlled, clinical and quality of life analysis.

Alimentary pharmacology & therapeutics·2018
Same author

Spectroscopic identification of r-process nucleosynthesis in a double neutron-star merger.

Nature·2017
Same author

Immunosuppressive drugs affect interferon (IFN)-γ and programmed cell death 1 (PD-1) kinetics in patients with newly diagnosed autoimmune hepatitis.

Clinical and experimental immunology·2017
Same author

Autoimmune hepatitis: From mechanisms to therapy.

Revista clinica espanola·2016
Same author

Measurement of the charge asymmetry in top quark pair production in <i>pp</i> collisions at [Formula: see text] using the ATLAS detector.

The European physical journal. C, Particles and fields·2015
Same journal

Mitral valve anomalies in transposition of the great arteries.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
Same journal

Oncologic Safety of Omitting Mediastinal Lymph Node Dissection in Segmentectomy for Ground-Glass Opacity-Dominant Lung Cancer: A Supplementary Analysis of JCOG1211.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
Same journal

Progress in Thymic Malignancy Care: The Imperative for Global Standards and Collaboration.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
Same journal

Association between interventional cardiologist practice characteristics, CABG use, and clinical outcomes.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
Same journal

The EACTS Innovation Committee's Perspective on the "Heart Valve of the Future".

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
Same journal

Why Should the Current Generation of Surgical Residents be Academically Active-Lessons From the Past.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
See all related articles

Heparin administration before cardiopulmonary bypass may activate the complement cascade. This study found complement activation during bypass, suggesting both classical and alternative pathway involvement.

Area of Science:

  • Immunology
  • Cardiovascular Surgery

Background:

  • The complement system plays a crucial role in innate immunity.
  • Cardiopulmonary bypass (CPB) is known to activate the complement system.
  • Understanding complement activation during CPB is vital for patient outcomes.

Purpose of the Study:

  • To investigate complement activation pathways during CPB for coronary artery surgery.
  • To determine the role of heparin in initiating complement activation.

Main Methods:

  • Measured plasma levels of complement components (C3, C4, factor B) and split products (C3d, C4d, Ba) in 12 patients.
  • Analyzed complement pathway activation through component levels and ratios before and during CPB.

Main Results:

Related Experiment Videos

  • Significant increases in Ba and C3d levels and Ba:B and C3d:C3 ratios were observed after heparin administration, preceding CPB.
  • During CPB, significant depletion of complement components and elevation of split products indicated activation of both classical and alternative pathways.
  • Statistical significance was noted for key markers (P < 0.05 and P < 0.01).

    • Conclusions:

    • Heparin administration may initiate alternative complement pathway activation.
    • Both classical and alternative complement pathways are activated during CPB.
    • This study elucidates complement activation during CPB and highlights heparin's potential role.