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Updated: May 12, 2026

Modeling Colitis-Associated Cancer with Azoxymethane (AOM) and Dextran Sulfate Sodium (DSS)
Published on: September 11, 2012
[The two-staged intervention for complicated colonic cancer]
This study introduces a modified Mikulicz operation for complex colon cancer, involving colonic resection and a two-stage anastomosis. The technique resulted in a low rate of 2.2% for anastomotic suture insufficiency.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Colorectal Surgery
Context:
- Complicated colonic cancer presents significant surgical challenges.
- The modified Mikulicz operation offers a novel approach for complex cases.
Purpose:
- To propose and evaluate a modified Mikulicz operation for complicated colonic cancer.
- To assess the efficacy and safety of a two-stage extraperitoneal invagination duplicature anastomosis.
Summary:
- The study details a surgical method involving colonic resection and a two-stage extraperitoneal invagination duplicature anastomosis for complicated colon cancer.
- This modified Mikulicz operation aims to improve outcomes in challenging colorectal cancer cases.
- Postoperative complications occurred in 10.9% of patients, with anastomotic suture insufficiency in 2.2%.
Impact:
- The proposed method demonstrates a low incidence of anastomotic complications, suggesting its potential clinical utility.
- This research contributes to the advancement of surgical techniques for managing complex colorectal malignancies.
- Further investigation may validate this approach for broader application in colonic cancer treatment.
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