Related Experiment Video

Updated: May 12, 2026

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates
08:32

Assessment of Intestinal Transcytosis of Neonatal Escherichia coli Bacteremia Isolates

Published on: February 17, 2023

Pathogenic Yersinia DNA in intestinal specimens of pediatric patients with Crohn's disease

Sarah B Leu1, Sarah Catherine Shulman, Charlotte Katherine Steelman

  • 1Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA.

Fetal and Pediatric Pathology
|April 25, 2013
PubMed

Insights

This study found Yersinia DNA in 9% of pediatric Crohn's disease colon specimens, suggesting a link. Further research is needed to understand Yersinia's role in pediatric Crohn's disease development.

Area of Science:

  • Gastroenterology
  • Microbiology
  • Pediatric Inflammatory Bowel Disease

Background:

  • A link between Yersinia and Crohn's disease is established in adults.
  • The role of Yersinia in pediatric Crohn's disease remains unclear.

Purpose of the Study:

  • To investigate the presence of Yersinia DNA in pediatric Crohn's disease colonic specimens.
  • To compare Yersinia prevalence in pediatric Crohn's disease patients with control groups.

Main Methods:

  • Polymerase chain reaction (PCR) assay used to detect Yersinia DNA.
  • Analyzed 77 colonic specimens from children with Crohn's disease.
  • Included control groups: 45 ulcerative colitis patients and 10 appendicitis patients.

Main Results:

  • Yersinia DNA was detected in 9% of pediatric Crohn's disease specimens.
  • No Yersinia DNA was found in control specimens (ulcerative colitis and appendicitis).
  • The difference in Yersinia presence was statistically significant (p = 0.0055).

Conclusions:

  • Findings support a potential association between Yersinia and pediatric Crohn's disease.
  • Further investigation is required to determine if Yersinia initiates or mediates pediatric Crohn's disease pathogenesis.

More Related Videos

Epithelial Cell Infection Analyses with Shigella04:56

Epithelial Cell Infection Analyses with Shigella

Published on: February 9, 2024

Analysis of Yersinia enterocolitica Effector Translocation into Host Cells Using Beta-lactamase Effector Fusions12:23

Analysis of Yersinia enterocolitica Effector Translocation into Host Cells Using Beta-lactamase Effector Fusions

Published on: October 13, 2015

Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.