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Elevated platelet activating factor level in ischemia-related arrhythmia and its electrophysiological effect on

Yong Kang Tao1, Shui Ping Zhao, Pu Lin Yu

  • 1Emergency Department, China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, China. taoyongkang@163.com

Biomedical and Environmental Sciences : BES
|April 25, 2013
PubMed

Insights

Platelet-activating factor (PAF) levels increase during acute myocardial infarction (AMI) and ischemia, correlating with fatal arrhythmias. PAF affects cardiac repolarization, potentially via ion channels.

Area of Science:

  • Cardiovascular Physiology
  • Cardiac Electrophysiology
  • Pharmacology

Background:

  • The precise mechanism of platelet-activating factor (PAF) in cardiac electrical disturbances and arrhythmias post-acute myocardial infarction (AMI) remains unclear.
  • Previous research suggests a role for ion channels in PAF's cardiac effects.

Purpose of the Study:

  • To elucidate the role of PAF in fatal arrhythmias following AMI.
  • To investigate the underlying electrophysiological mechanisms of PAF's action in the context of myocardial infarction and ischemia.

Main Methods:

  • Measurement of blood PAF levels and continuous electrocardiogram (ECG) monitoring in 72 AMI patients.
  • Ischemia simulation and ECG recording in 20 pigs, with concurrent PAF level measurements.
  • In vitro studies using guinea pig papillary muscles involving PAF perfusion and microelectrode recordings.

Main Results:

  • Elevated PAF levels were observed in human AMI patients and pigs with simulated ischemia, with significantly higher levels during fatal arrhythmias.
  • In guinea pig myocardium, PAF induced action potential duration shortening (APD90) under both non-ischemic and simulated ischemic conditions.
  • The effect of PAF on APD90 was more pronounced under simulated ischemic conditions.

Conclusions:

  • Acute myocardial infarction and ischemia are linked to increased PAF levels in humans and pigs.
  • Further elevation of PAF occurs when fatal arrhythmias develop post-AMI or ischemia.
  • PAF's myocardial effects are likely mediated through interactions with multiple cardiac ion channels.
Abstract

Keywords:
Acute myocardial infarctionFatal arrhythmiaIschemiaPlatelet activating factor (PAF)

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