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Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance
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Decorating metal oxide surfaces with fluorescent chlorosulfonated corroles.

Carl M Blumenfeld1, Robert H Grubbs, Rex A Moats

  • 1Department of Chemistry, California Institute of Technology, Pasadena, California 91125, United States.

Inorganic Chemistry
|April 25, 2013
PubMed
Summary

New corrole compounds and their metal complexes were synthesized and conjugated with titanium dioxide nanoparticles. These conjugates show potential as contrast agents for noninvasive optical imaging applications.

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Area of Science:

  • Organic Chemistry
  • Materials Science
  • Nanotechnology

Background:

  • Corroles are macrocyclic compounds with unique photophysical properties.
  • Titanium dioxide nanoparticles (TiO2 NPs) are widely used in various applications.
  • Functionalization of nanoparticles can enhance their properties for specific uses.

Purpose of the Study:

  • To synthesize novel bis(chlorosulfonyl)corrole derivatives and their aluminum(III) and gallium(III) metal complexes.
  • To conjugate these corrole derivatives and their metal complexes with TiO2 nanoparticles.
  • To evaluate the potential of these corrole-TiO2 NP conjugates as contrast agents for optical imaging.

Main Methods:

  • Synthesis and characterization of corrole compounds and metal complexes using NMR, mass spectrometry, and electronic absorption spectroscopy.

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  • Conjugation of corrole-TiO2 NP conjugates.
  • Surface characterization using FTIR, X-ray photoelectron spectroscopy, and confocal fluorescence imaging.

    • Main Results:

    • Successful synthesis and characterization of 2,17-bis(chlorosulfonyl)-5,10,15-tris(pentafluorophenyl)corrole and its aluminum(III) and gallium(III) complexes.
    • Formation of stable corrole-TiO2 NP conjugates.
    • Confocal fluorescence imaging revealed promising imaging capabilities for Al-corrole-TiO2 and Ga-corrole-TiO2 conjugates.

    Conclusions:

    • The synthesized corrole derivatives and their metal complexes can be effectively conjugated with TiO2 nanoparticles.
    • The resulting corrole-TiO2 NP conjugates exhibit fluorescence properties suitable for optical imaging.
    • These novel nanomaterials hold promise as contrast agents for noninvasive optical imaging.