Related Experiment Video
Updated: May 12, 2026
06:51
Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome
Published on: July 28, 2023
Factors affecting the severity of necrotizing enterocolitis
Cheryl A Miner1, Susan Fullmer, Dennis L Eggett
1NICU, Utah Valley Regional Medical Center , Provo, UT , USA .
Summary
Necrotizing enterocolitis (NEC) severity is linked to early feeding practices and red blood cell (RBC) transfusions. Ensuring early colostrum intake and minimizing transfusions may reduce NEC severity and improve infant outcomes.
Area of Science:
- Neonatal Medicine
- Pediatric Surgery
- Gastroenterology
Background:
- Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease in neonates with variable outcomes.
- Factors influencing NEC severity remain largely unknown, necessitating further investigation.
Purpose of the Study:
- To identify statistical associations between clinical factors and the severity of necrotizing enterocolitis (NEC) in neonates.
- To explore potential strategies for mitigating NEC severity and improving patient outcomes.
Main Methods:
- Retrospective, multi-institutional, multiyear study of neonates diagnosed with confirmed NEC.
- Analysis of clinical data, including laboratory values and feeding practices, in relation to NEC Bell's stage.
Main Results:
- Elevated C-reactive protein, immature to total neutrophil ratio, mean platelet volume, low pH, and low platelet count were associated with progression to severe NEC (Stage III).
- Antecedent red blood cell (RBC) transfusion and non-colostrum initial feedings significantly increased the odds of severe NEC.
- Low pH and lack of early colostrum were the strongest predictors of mortality from NEC.
Conclusions:
- Strategies aimed at reducing RBC transfusions and ensuring early colostrum feedings are promising avenues for decreasing NEC severity.
- These findings provide a basis for developing targeted interventions to improve outcomes for infants with NEC.
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