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Blood Transfusion and Agglutination

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
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The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...

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Related Experiment Video

Updated: Jan 7, 2026

Routine Screening Method for Microparticles in Platelet Transfusions

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

Improving Platelet Transfusion Practice.

Robert D Christensen^1,2, Patricia Davenport³, Martha C Sola-Visner³

¹Division of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, Utah.

|December 31, 2025

Summary

This summary is machine-generated.

Neonatal platelet transfusions can be lifesaving but carry risks. Evidence-based transfusion practices and stewardship programs are crucial for improving outcomes in critically ill infants receiving platelet therapy.

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Published on: February 14, 2017

Area of Science:

Neonatal Medicine
Hematology
Pediatric Critical Care

Background:

Platelet transfusions are common in neonatal intensive care units.
While beneficial, neonatal platelet transfusions carry significant risks.
Research is ongoing to understand risks and improve disease pathogenesis understanding.

Purpose of the Study:

Clarify associations between platelet transfusions and adverse infant outcomes.
Raise awareness of high-risk neonates for multiple transfusions.
Promote evidence-based, restrictive transfusion practices.

Main Methods:

Review of preclinical and clinical research.
Analysis of existing literature on neonatal transfusion risks and benefits.
Identification of high-risk patient populations.

Main Results:

Neonatal platelet transfusions from adult donors are linked to dose-dependent risks.
Adverse outcomes include major bleeding, bronchopulmonary dysplasia, and neurodevelopmental issues.
Restrictive transfusion strategies may mitigate risks.

Conclusions:

Transfusion stewardship programs improve neonatal outcomes.
Clinicians should apply evidence-based practices for neonatal platelet transfusions.
Novel treatments for neonatal thrombocytopenia are under investigation.