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Association of aneurysms and variation of the A1 segment

A Krasny1, F Nensa, I E Sandalcioglu

  • 1Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany.

Journal of Neurointerventional Surgery
|April 25, 2013
PubMed

Insights

Anatomical variations in the anterior cerebral artery (ACA) A1 segment are linked to a higher occurrence of anterior communicating artery (ACoA) aneurysms. This finding suggests a correlation between circle of Willis morphology and aneurysm prevalence.

Area of Science:

  • Neurology
  • Vascular Neurology
  • Neuroimaging

Background:

  • Cerebrovascular diseases are associated with variations in the circle of Willis.
  • Anterior cerebral artery (ACA) anatomical variations may correlate with anterior communicating artery (ACoA) aneurysm prevalence.

Purpose of the Study:

  • To investigate the prevalence of aneurysms in patients with anatomical/morphological variations of the circle of Willis.
  • To assess the relationship between ACA variations and ACoA aneurysms.

Main Methods:

  • Retrospective analysis of 223 patients undergoing cerebral angiography for ACoA aneurysm.
  • Review of diagnostic imaging to identify circle of Willis anomalies, aneurysm size, and rupture.
  • Comparison with 204 control patients with unrelated diagnoses.

Main Results:

  • A1 segment variations were significantly more frequent in the aneurysm group compared to controls.
  • Mean aneurysm size differed based on the grade of A1 segment hypoplasia or aplasia.

Conclusions:

  • Variations in the A1 segment of the ACAs are correlated with a higher prevalence of ACoA aneurysms.
  • A symmetric circle of Willis is associated with a lower prevalence of ACoA aneurysms.
Abstract

Keywords:
AneurysmAngiographyHemorrhage

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