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Updated: May 12, 2026
08:57
Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin
Published on: August 14, 2018
Eukaryotic DNAJ/K Database: A Comprehensive Phylogenomic Analysis Platform for the DNAJ/K Family
Kyeongchae Cheong1, Jaehyuk Choi, Jaeyoung Choi
1Fungal Bioinformatics Laboratory, Seoul National University, Seoul 151-921, Korea. ; Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea.
Genomics & Informatics
|April 25, 2013
Summary
The Eukaryotic DNAJ/K Database (EDD) was created to study molecular chaperone proteins. This database aids in understanding the evolution and comparative genomics of DNAJ/K families across eukaryotes.
Area of Science:
- Molecular Biology
- Genomics
- Evolutionary Biology
Background:
- DNAJ/K proteins are essential molecular chaperones found across all domains of life.
- Understanding their evolutionary relationships is crucial for comprehending cellular functions.
- Previous systematic analyses of these protein families in eukaryotes were limited.
Purpose of the Study:
- To develop a comprehensive database for the systematic phylogenomics of eukaryotic DNAJ/K protein families.
- To provide a resource for comparative genomic analyses of these important chaperone proteins.
- To gain new insights into the evolutionary relationships within the DNAJ/K families across different eukaryotic kingdoms.
Main Methods:
- Development of the Eukaryotic DNAJ/K Database (EDD).
- Identification and cataloging of DNAJ and DNAK proteins from 339 eukaryotic genomes.
- Implementation of 'class', 'cluster', and 'taxonomy' browsers for data exploration.
- Inclusion of a 'favorite' function for user customization.
Main Results:
- The EDD contains 12,908 DNAJ and 4,886 DNAK proteins from 339 eukaryotic genomes.
- A kingdom-wide comparison of DNAJ/K families was performed.
- New insights into the evolutionary relationships within these protein families were generated.
Conclusions:
- The Eukaryotic DNAJ/K Database (EDD) is a valuable resource for phylogenomic and comparative genomic studies.
- The database facilitates a deeper understanding of the evolution of molecular chaperones in eukaryotes.
- EDD provides a versatile platform for researchers studying DNAJ/K protein families.
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