Related Experiment Video
Updated: May 12, 2026
07:15
In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis
Published on: October 20, 2013
[Pigmented villonodular synovitis of the knee]
F Smets1, W Kurth, J M Crielaard
1Université de Liège, Belgique.
Revue Medicale De Liege
|April 26, 2013
Summary
Pigmented villonodular synovitis (PVNS) is a rare knee disorder. Surgical excision is the primary treatment for PVNS, though recurrence is common.
Area of Science:
- Orthopedics
- Pathology
Background:
- Pigmented villonodular synovitis (PVNS) is a rare, typically benign proliferative disorder affecting the knee joint.
- The exact etiology of PVNS remains unknown, presenting diagnostic and therapeutic challenges due to non-specific symptoms and high recurrence rates.
Observation:
- A case report details a 30-year-old patient diagnosed with knee PVNS.
- The patient underwent orthopedic surgery for lesion removal.
Findings:
- Magnetic Resonance Imaging (MRI) is crucial for lesion visualization.
- Definitive diagnosis of PVNS requires anatomopathologic analysis of surgically excised tissue.
Implications:
- Surgical excision via arthrotomy or arthroscopy is the standard treatment for PVNS.
- Early diagnosis and complete lesion removal are critical to minimize PVNS recurrence.
Related Concept Videos
01:23Knee Joint
The knee joint is the most complicated joint in the body. It consists of three articulations– two tibiofemoral and one patellofemoral. As is characteristic of synovial joints, the knee joint has a thin articular capsule that partially surrounds this joint cavity. Additionally, several ligaments, muscles, and cartilaginous structures support the movement of the knee.
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris group...
A total of seven ligaments support the knee joint. The patellar ligament, which is also attached to the quadriceps femoris group...
01:07Development of the Limb Synovial Joints
Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
01:24Nephrotic Syndrome I : Introduction
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
01:10Ankle Joint
The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
01:20Inflammatory Bowel Disease IV: Clinical Manifestations
Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
01:25Inflammatory Bowel Disease III: Crohn's Disease
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...