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Updated: May 12, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Psoriasis clinical implications and treatment: a review
Ashlesha S Raut1, Rashmi H Prabhu, Vandana B Patravale
1Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Nathalal Parekh Marg, Matunga, Mumbai 400 019, India.
Critical Reviews in Therapeutic Drug Carrier Systems
|April 26, 2013
Summary
Psoriasis is a T-cell mediated autoimmune skin disorder with unknown etiology. Current treatments aim to manage symptoms and T-cell proliferation, with newer therapies like biologics offering advanced options.
Area of Science:
- Dermatology
- Immunology
- Genetics
Background:
- Psoriasis is a prevalent, T-cell mediated autoimmune skin disorder characterized by keratinocyte hyperproliferation.
- While genetic predisposition is known, the exact etiology of psoriasis remains elusive.
- The disease presents with diverse clinical manifestations and affects individuals globally.
Purpose of the Study:
- To review current understanding of psoriasis pathogenesis.
- To explore the evolution and variety of treatment modalities for psoriasis.
- To highlight advancements in psoriasis therapy, including novel approaches.
Main Methods:
- Literature review of psoriasis pathogenesis and treatment strategies.
- Analysis of historical and current therapeutic interventions.
- Examination of emerging treatments such as biologics and gene therapy.
Main Results:
- Psoriasis pathogenesis involves T-cell activation and keratinocyte hyperproliferation.
- Treatment has evolved from topical agents to systemic therapies and light therapy.
- Newer approaches like biologics and gene therapy represent significant advancements.
Conclusions:
- Current psoriasis treatments effectively manage symptoms but carry risks of side effects.
- Combination therapies and novel drug delivery systems aim to enhance efficacy and reduce adverse events.
- While no cure exists, ongoing research in biologics and gene therapy offers revolutionary potential for managing psoriasis.
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