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Published on: December 23, 2013
Poly(lactic-co-glycolic) acid-controlled-release systems: experimental and modeling insights
Daniel J Hines1, David L Kaplan
1Department of Chemical and Biological Engineering, Tufts University, Medford, Massachusetts, USA.
Critical Reviews in Therapeutic Drug Carrier Systems
|April 26, 2013
Summary
Poly(lactic-co-glycolic acid) (PLGA) is a key polymer for controlled drug delivery. Understanding PLGA properties and using mathematical modeling optimizes drug release from these advanced delivery systems.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Pharmaceutical Sciences
Background:
- Poly(lactic-co-glycolic acid) (PLGA) is a widely successful polymeric biomaterial in controlled drug delivery.
- The chemical and physical properties of PLGA significantly influence drug release kinetics from delivery devices.
Purpose of the Study:
- To review the advantages and limitations of PLGA for controlled drug release.
- To discuss current PLGA-based controlled-release technologies.
- To explore the application of mathematical modeling in understanding PLGA drug release.
Main Methods:
- Literature review of PLGA properties and applications in drug delivery.
- Analysis of mathematical modeling approaches for controlled release.
- Synthesis of current state-of-the-art understanding of PLGA-based systems.
Main Results:
- PLGA offers tunable properties for drug release control.
- Mathematical modeling aids in characterizing and predicting drug release mechanisms.
- Optimization of PLGA properties is crucial for effective formulation.
Conclusions:
- PLGA remains a leading biomaterial for controlled drug delivery.
- Integrated understanding of PLGA properties and mathematical modeling enhances device design.
- Further research can refine control over drug release profiles.
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