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Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
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Towards real-time VMAT verification using a prototype, high-speed CMOS active pixel sensor.

Hafiz M Zin1, Emma J Harris, John P F Osmond

  • 1Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey, SM2 5PT, UK. hafiz.zin@gmail.com

Physics in Medicine and Biology
|April 26, 2013
PubMed
Summary
This summary is machine-generated.

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This study shows a prototype complementary metal oxide semiconductor active pixel sensor (CMOS APS) can verify volumetric modulated arc therapy (VMAT) in real-time. The fast, large-format sensor accurately tracks treatment delivery, demonstrating its potential as a radiotherapy dosimeter.

Area of Science:

  • Medical Physics
  • Radiotherapy Technology
  • Sensor Technology

Background:

  • Advanced radiotherapy techniques like Volumetric Modulated Arc Therapy (VMAT) require precise real-time verification.
  • Traditional verification methods may not fully meet the demands of complex VMAT deliveries.
  • Active Pixel Sensors (APS) offer potential for high-speed imaging crucial for treatment verification.

Purpose of the Study:

  • To investigate the feasibility of a prototype complementary metal oxide semiconductor active pixel sensor (CMOS APS) for real-time VMAT verification.
  • To assess the performance of a large-format CMOS APS with fast imaging capabilities.

Main Methods:

  • Utilized a prototype CMOS APS with region of interest readout for high-speed imaging (up to 403.6 f/s).
  • Employed an automatic edge tracking algorithm to monitor multi-leaf collimator (MLC) leaf motion.

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  • Evaluated fluence distribution accuracy using gamma analysis (3%/3 mm) at a sampling rate of 50.4 f/s.

    • Main Results:

    • The CMOS APS successfully tracked MLC leaves moving at 18 mm/s with sub-millimeter accuracy (<1.0 mm).
    • Measured fluence distributions closely matched planned distributions, achieving an average gamma pass rate of 96%.
    • The system demonstrated the capability to measure MLC motion and linac pulse rate variations during VMAT delivery.

    Conclusions:

    • The prototype CMOS APS is feasible for real-time VMAT verification.
    • The sensor's fast imaging and tracking capabilities are suitable for complex radiotherapy treatments.
    • CMOS APS technology shows significant potential as a real-time radiotherapy dosimeter for VMAT.