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Updated: May 12, 2026
Multicolor Flow Cytometry Analyses of Cellular Immune Response in Rhesus Macaques
Published on: April 22, 2010
Changes in blood parameters in rhesus monkeys (Macaca mulatta) during the first trimester of gestation
Alejandra Ibáñez-Contreras1, Braulio Hernández-Godínez, Sergio A Reyes-Pantoja
1Centro de Investigación, Proyecto CAMINA, A.C., Ciudad de México, México D.F, México. ibanez.alejandra@hotmail.com
Background:
Regarding the good practice in the laboratory work, it is essential to have a broad spectrum of biochemical and hematological references in pregnant females to determine the health status of the colony.
Objective:
To establish reference values to reveal changes in hematology and blood chemistry in pregnant rhesus monkeys (Macaca mulatta) in their first trimester of pregnancy.
Methods:
Twenty-eight females in reproductive stage were used, divided into two groups: 14 pregnant macaques in their first trimester and 14 non-pregnant used as the control group. Blood samples were collected for the hematological test and blood chemistry.
Results:
The results showed significant difference in the blood chemistry for the following parameters: glucose, total bilirubin, and total protein. The hematological evaluation revealed significant difference in leukocytes and neutrophils.
Conclusions:
These findings offer a reference range and provide a basis for improvement in techniques and refinement of clinical processes in these specimens.
