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Type II diabetes mellitus and menopause: a multinational study
A Monterrosa-Castro1, J E Blümel, K Portela-Buelvas
1Universidad de Cartagena , Cartagena , Colombia.
Summary
Type II diabetes mellitus is linked to early menopause, particularly in women under 45. However, menopause does not increase the risk of developing type II diabetes. This study explored risk factors and impacts on women's health.
Area of Science:
- Endocrinology
- Reproductive Health
- Metabolic Disorders
Background:
- Type II diabetes mellitus (T2DM) is associated with metabolic changes that can precipitate early menopause.
- These metabolic alterations may also exacerbate climacteric symptoms in women.
Purpose of the Study:
- To identify risk factors associated with T2DM in women.
- To evaluate the influence of T2DM on the age of menopause onset.
- To assess the impact of T2DM on the severity of climacteric symptoms.
Main Methods:
- A cross-sectional study involving 6079 women aged 40-59 from 11 Latin American countries.
- Participants completed the Menopause Rating Scale and Goldberg Anxiety-Depression Scale.
- Statistical analysis included odds ratios (OR) and 95% confidence intervals (CI) to assess associations.
Main Results:
- The prevalence of diabetes was 6.7%.
- T2DM was associated with hypertension, psychotropic drug use, hormonal therapy, age ≥ 50, overweight/obesity, and increased waist circumference.
- Lower diabetes risk was observed with hormonal contraceptive use, alcohol consumption, and residing at higher altitudes or in warmer climates.
- Diabetes significantly increased the risk of menopause before age 45 but did not worsen quality of life due to climacteric symptoms.
Conclusions:
- Menopause does not elevate the risk of developing T2DM.
- T2DM is a significant risk factor for early menopause, specifically in women under 45 years old.
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