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Updated: May 12, 2026
06:51
Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome
Published on: July 28, 2023
Clinical and surgical aspects in necrotizing enterocolitis
R N Bălănescu1, L Topor, G C Drăgan
1Department of Pediatric Surgery, "Grigore Alexandrescu" Emergency Hospital for Children, Bucharest, Romania.
Chirurgia (Bucharest, Romania : 1990)
|April 27, 2013
Summary
Clinical and radiological factors may predict outcomes in neonatal necrotizing enterocolitis (NEC). Later symptom onset in NEC patients indicates a more severe condition and higher mortality risk, even after surgery.
Area of Science:
- Neonatal surgery
- Pediatric gastroenterology
- Clinical outcomes research
Background:
- Necrotizing enterocolitis (NEC) is a severe gastrointestinal emergency in neonates.
- Surgical intervention for NEC carries significant risks and high mortality rates.
- Predictive factors for NEC progression and mortality require further investigation.
Purpose of the Study:
- To determine if clinical and radiological parameters can predict NEC pathology progression.
- To assess the necessity of laparotomy in neonates with peritoneal drains.
- To identify predictors of mortality in surgically treated NEC patients.
Main Methods:
- Retrospective review of 51 NEC cases (2005-2011).
- Collection of patient demographics, clinical data, and radiological findings.
- Analysis of outcomes including progression, surgical intervention, and mortality.
Main Results:
- The study included 51 neonates (56.8% male) with a mean age of 18.71 days.
- Mean birth weight was 1979.6g; mortality rate was 45% (23/51 patients).
- Bell stage III NEC indicated surgery but was associated with high fatality.
Conclusions:
- The overall mortality for surgically treated NEC in this series was 45%.
- Patients undergoing surgery had a higher likelihood of mortality compared to non-surgical cases.
- A later onset of NEC symptoms is a significant alarm sign for disease severity and poor prognosis.
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